Biological DNA Sensor PDF
By:Sivapriya Kailasan Vanaja,Vijay A.K. Rathinam,Katherine A. Fitzgerald
Published on 2013-10-30 by Elsevier Inc. Chapters
The innate immune response serves as the first line of defense against microbial infections by detecting pathogen-associated molecular patterns through germline-encoded pattern recognition receptors. Proteins of the PYHIN family have gained substantial research focus in recent years as central mediators of innate immune responses induced by cytosolic microbial DNA. Sensing of DNA by PYHINs typically leads to activation of inflammasomes and/or type I interferon responses that are crucial for host defense against invading pathogens. Certain members of the family are also involved in the development of autoimmune diseases as well as transcriptional regulation. Although the generation of knockout mice strains has unraveled the essential role of PYHIN proteins such as AIM2 in the development of antimicrobial innate immune responses, the exact biological role of several other PYHIN family members remains to be understood. This chapter reviews the important discoveries on PYHIN proteins and their role in microbial defense, autoimmunity and transcriptional regulation.
This Book was ranked at 4 by Google Books for keyword biology about dna.
Book ID of Biological DNA Sensor's Books is wTx1DAAAQBAJ, Book which was written bySivapriya Kailasan Vanaja,Vijay A.K. Rathinam,Katherine A. Fitzgeraldhave ETAG "0tV1z33uFU8"
Book which was published by Elsevier Inc. Chapters since 2013-10-30 have ISBNs, ISBN 13 Code is 9780128068755 and ISBN 10 Code is 0128068752
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